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First-year BMI change was measured using the difference between baseline BMI and the average BMI recorded between 275 and 455 days after treatment started

The most reasonable choice depends on the clinical objective, formulation quality, route, tolerance, convenience and evidence proportional to the claim being made

Stones can migrate from the gallbladder into the bile ducts (choledocholithiasis), potentially causing obstruction, jaundice, or acute pancreatitis