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In addition to experimental methods, theoretical methods [49,50,51,52,53] have been used to elucidate the properties and mechanisms of vitamin B12 cofactor catalysis in enzymatic processes [54,55,56,57,58,59]
However, there are examples of drugs being withdrawn from the market as more long-term data comes to light
N Engl J Med 2008;358:25602572
Chemical Structure Technical Specifications The peptide contains two non-coded amino acid residues (aminoisobutyric acid) at positions 2 and 13, which significantly reduce susceptibility to dipeptidyl peptidase-4 (DPP-4) degradation
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