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Key participants include Bachem, PolyPeptide Group, CordenPharma, Lonza, and WuXi STA, which collectively account for an estimated 80% of the outsourced semaglutide and tirzepatide API CDMO market, owing to their established commercial manufacturing infrastructure and significant investments in GLP-1 peptide capacity expansion
[2] Weight regain after withdrawal of semaglutide (STEP 1 extension) PMC
However, it's important to note that oral semaglutide (Rybelsus) must be taken in the morning on an empty stomach according to its FDA labeling
Its established track record and immediate availability make it the practical choice for most patients
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