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Another option would be to stratify all participants into subgroups by percentage of weight lost and evaluate how well the stratification correlates with MACE
Thus, the Guidance for Industry specifically directs the inclusion of high-risk populations in CVOTs: those at high CV risk, those with advanced disease, elderly patients, and those with some degree of renal dysfunction
PubMed laboratory research record [PMID: 37640171] PubMed record related to this compound for laboratory literature review
1975 Apr;72(4):1317-21.] And that raises additional questions about the safety of this product
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