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not recommended for use with DPP-4 inhibitors Common side effects : Gastrointestinal symptoms (nausea, vomiting, diarrhea) that typically diminish with continued use and proper dose titration Referral to endocrinology or obesity medicine specialists is appropriate for complex cases, including patients with multiple failed therapies, significant comorbidities, or those requiring comprehensive weight management programs

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Role of obesity, mesenteric adipose tissue, and adipokines in inflammatory bowel diseases