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First study that showed that the incretin effect is markedly reduced in patients with T2DM
Insert the needle into the vial stopper, inject the air (this equalizes pressure and makes drawing easier), then invert the vial and draw the peptide solution to the correct graduation mark on the syringe
The added glucagon receptor increases resting energy expenditure, promotes liver fat clearance (82% reduction vs ~55%), and contributes to greater overall weight loss (28.7% vs 22.5%)
Phase 2 data shows a favorable safety profile, but Phase 2 trials are small (338 participants)
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