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This caused glutamate deficiency subjecting the cells to GSH depletion and thus the observed ROS accumulation that led to apoptosis [23]
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The role of autophagy and mitophagy in the heart Given the unique physiology and limited regenerative capacity of cardiomyocytes, autophagy and its mitochondria-selective subtype, mitophagy, collectively emerge as two of the most vital mechanisms for maintaining cardiac proteostasis and long-term myocardial health
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