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Physiological phases like lactation or pregnancy gave no statistically significant differences (Figure 1a) (Supplementary Table S3)
Lead series optimization Our goal was to enhance interactions of the small-molecule agonists with the GLP-1R through lowering the energy barrier to achieve the receptor-bound agonist conformation, and by adjusting polar substituents, with minimal increases in molecular weight
Another common side effect associated with GLP-1 agonists is headaches
2017;43(Suppl 1):2S139
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