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Blood 105(5):21612167 Paul BT et al (2017) Mitochondria and Iron: current questions

Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)

Quantitative real-time PCR Cells and tissues were first lysed using Trizol, then the total RNA was extracted with RNA Easy Fast Tissue/Cell Kit (Tiangen, city, ST, Ctry

Moreover, growth hormone actively participates in metabolic activities, enhancing the utilization of fats for energy and sparing glucose