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The mutation frequency in the studied group was significantly higher among men than women (24.34% and 10.67%, respectively) ( SF3BP1 likely pathogenic variants were identified only in 2.5% (7 out of 282) PRL-secreting PAs
The increased cAMP levels in cardiac cells activate exchange protein directly activated by cAMP (EPAC) and protein kinase A (PKA), which regulate a multitude of downstream effectors involved in cardiac contractility, relaxation, and hypertrophy [14]
The right complementary approach turns good results into transformative ones
( Epub 2019/05/15 )
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