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demonstrated that inducing ER stress via TRAIL-Rs significantly decreased MDSC viability in tumor-bearing mice, contributing to the breakdown of the immunosuppressive environment
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For example, in exploratory trials for Alzheimers disease, a specialized oral formulation of MB (methylthioninium chloride, brand name LMTM) was studied at doses as low as 4 mg twice daily (8 mg total per day) and showed some promise in slowing cognitive decline
L.Ortega-VillasanteC.et al (2015)
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