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Tirzepatide and retatrutide, which have dual agonist activities targeting both GLP-1 receptor and GIP receptor (GIPR) or GLP-1 receptor and glucagon receptor (GCGR), respectively, have been shown to improve energy expenditure and metabolic flexibility in other studies [50, 51]
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, et al
Arginine metabolism also appears relevant
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