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In vitro experiments demonstrated that Akt inhibition markedly upregulated the expression of FTL, FTH, TFR1, and Poly (rC)-binding protein 1 (PCBP1), downregulated FPN1 expression, increased APP expression, enhanced iron storage and uptake, and decreased iron efflux, thereby aggravating neurological injury in SH-SY5Y and C2C12 cells (Halon-Golabek et al., 2024)

MIC injections can serve as an early step in that continuum, helping patients explore metabolic support while they evaluate whether more targeted procedures might be appropriate for their goals

Collectively, these findings point to a correlation between the effects of L-carnitine on mitigating oxidative stress and inflammation and its effects on lowering ACE2, TMPRSS2 and furin