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The Widmark r factor values (0.66 and 0.73) are derived from cisgender population studies and represent population averages, not individual measurements
It is a modification of amino acids 176-191
Useful target-engagement readouts may include reduced 1-methylnicotinamide formation, changes in nicotinamide-related metabolites, and confirmation that the selected cellular or tissue model expresses NNMT at a level relevant to the experimental question
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