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Conflict of interest The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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The results confirmed that, except for some loci where effective SNPs could not be selected due to issues during data alignment, the expression of the PNKP gene in the anterior cingulate cortex (BA24), cerebral cortex, nucleus accumbens, and putamen, as well as the expression of the MRVI1 gene in the anterior cingulate cortex (BA24) and substantia nigra, were significantly associated with migraine risk, with effect directions consistent with previous findings