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Unlike other weight-loss medications, GLP-1s mimic a gut-based, appetite-modulating hormone that decreases blood sugar levels and sends signals of fullness to the brain

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Sample sizes are smaller than those used in phase 3 trials, and results may not fully reflect outcomes in more diverse, real-world populations

A 2023 study published in JAMA Ophthalmology examined over 16,000 patients and found a small but statistically significant increased risk of certain retinal complications in those prescribed semaglutide compared to other diabetes medications