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Optimizing thyroid hormone replacement is the essential first stepensuring TSH levels are within the laboratory-specific reference range maximizes metabolic function and creates a more favorable environment for weight management

Some practical planning strategies include: Preparing meals in advance to avoid reaching for convenience foods when appetite is low or unpredictable Eating slowly and mindfully , chewing thoroughly to ease the digestive burden Stopping eating at the first sign of fullness slowed gastric emptying means satiety signals may arrive more abruptly than expected Including a source of protein at every meal to support muscle preservation For people managing retatrutide alongside type 2 diabetes, particularly those also taking insulin or sulfonylureas, there is an increased risk of hypoglycaemia as food intake decreases

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GLP-1 RAs are contraindicated during pregnancy due to limited safety data and potential embryofetal risk