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J Pharm Biomed Anal (2013) 72(0):1216.10.1016/j.jpba.2012.09.029 72 MenendezJAVazquez-MartinAColomerRBrunetJCarrasco-PancorboAGarcia-VillalbaRet alOlive oils bitter principle reverses acquired autoresistance to transtuzumab (Herceptin TM ) in HER-overexpressing breast cancer cells

Satiety: Including protein in meals and snacks enhances satiety and helps prevent overeating by slowing digestion and prolonging the release of hunger-suppressing hormones like GLP-1

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While timing alone is unlikely to be the sole cause, it is one piece of the optimization puzzle that is easy to adjust and test