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This phenomenon underscores the importance of understanding that tolerance does not equate to immunity against alcohols toxic effects. In summary, while tolerance masks the immediate sensations of intoxication, it does not protect against the physiological dangers of excessive alcohol consumption

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Therefore, fetal programming of BBB permeability by hypoxia and IUGR pose a unique challenge to the scientific community in searching for involved mechanisms and effective clinical treatment to prevent detrimental postnatal outcomes