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Although these mice initially exhibit normal cardiac function, they progressively develop left ventricular dilation, reduced fractional shortening, disorganized sarcomeres, and damaged mitochondria with aging, highlighting the essential role of sustained autophagy in maintaining structural integrity and contractile function over time
2007 Sep;28(9):1960-4
Sources: Novinscak T, Brcic L, Staresinic M, et al
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