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OP is a common clinical disorder mainly characterized by bone mass loss and bone microarchitectural deterioration (97)
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Samples were incubated for 4 h with 1 nM streptavidin cryptate (Cisbio), 0.05-0.5 nM of biotinylated PCSK9 and 0.12 nM of labelled anti-PCSK9 antibody
In consideration of the multiple metabolic and cardiovascular effects seen in subjects treated with GLP-1RAs and SGLT-2is (e.g., reduction of hyperglycemia, weight loss, free/fat mass and bone remodeling, anti-atherosclerosis, natriuresis), it is reasonable to speculate that GH and IGF-1 may play a about a relevant role in this context
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