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Diabetic patients present with chronic hyperglycemia, and elevated glucose levels together with canonical hyperglycemia-associated metabolic pathways (polyol pathway, hexosamine pathway, protein kinase C activation, and advanced glycation end product accumulation) induce excessive ROS production to trigger oxidative stress (152155)

Huang S, Liu H, Lin Y, Liu M, Li Y, Mao H, Zhang Z, Zhang Y, Ye P, Ding L

Management believes that by applying the flexible titration learnings from REDEFINE-1, this trial (reporting in H1 2027) will finally bridge the efficacy gap with Lilly

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