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Loffreda S, Yang SQ, Lin HZ et al (1998) Leptin regulates proinflammatory immune responses

Although glutamate is the major downstream product of glutamine, glutamate supplementation during glutamine deprivation cannot rescue the impaired cell growth or mitochondrial respiration 16,43,44,45 , indicating that mitochondrial GLS-catalyzed cleavage of the gamma-nitrogen of glutamine is essential for glutaminolysis

Pharmaceutical-strength formulations at the higher end of that range cost more but contain higher active concentrations

If you waste money testing someones B12 levels on 3 monthly injections they are all overr the upper normal range