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Anecdotally, many researchers working on specific, localized injuries prefer localized administration, believing it provides a more targeted and potent effect

The honest position is this: there is no head-to-head human bioavailability trial telling you which route is superior for this specific molecule, so the best route is not a settled question

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NTS were purified by layering on 4 C Percoll gradient suspension containing Eagles minimum essential medium, penicillin-streptomycin (10,000 U per ml penicillin/10,000 U per ml streptomycin), and 1 M HEPES in 0.85% NaCl with cercariae suspension and centrifuged at 500 g for 15 min