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Despite their advantages, liposomes also have several stability problems, such as aggregation, drug leakage, sedimentation, and fusion, as well as phospholipid hydrolysis, oxidation, or both
This makes them especially useful for people who cannot absorb B12 effectively through their diet or supplements
The most practical approach for many protocols involves starting with a 5mg vial for the early escalation phases and switching to a 10mg vial once weekly doses are higher
Informal protocols generally avoid doubling the next amount because safety and dose limits are unknown
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