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Clinical experience targeting T2DM has shown that the 3 mg dose is more effective than the 1.8 mg dose in managing T2DM in combination with other hypoglycemic drugs and improving weight
Despite the encouraging results of GLP-1/glucagon co-agonism in experimental models, different GLP-1 and glucagon co-agonists have shown various levels of efficacy and tolerability in people with obesity and/or T2D, in early phase clinical trials, which may be explained by the different ratio of GLP-1 to glucagon activity between the different molecules [65]
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