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Retatrutide (LY3437943) is an investigational, synthetic peptide designed as a tri-agonist at the GIP, GLP-1, and glucagon receptors

Together, these three mechanisms create a uniquely comprehensive metabolic research tool unlike any single or dual agonist

During the SURPASS trials, which assessed the safety of tirzepatide, many people taking tirzepatide experienced gastrointestinal side effects

While mild hypercapnia alone is unlikely to trigger amyloid formation, the cumulative interplay of chronic disease, inflammation, impaired clearance pathways, and aging-associated acidification may lower the threshold at which misfolding and aggregation become pathophysiologically relevant