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This configuration supports receptor-level interaction within adipocytes while minimizing affinity for the growth hormone receptor, distinguishing it from full-length GH and preventing downstream IGF-1 pathway activation

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AOD-9604 is a 16-amino-acid fragment of hGH (residues 177191 with an N-terminal Tyr added), whereas full hGH is a 191-amino-acid protein

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Given these potential mechanisms, this study was designed to test the hypothesis that DIO mice restored to the weight and adiposity of LD controls through NNMTi treatment and LD switch 13 have a similar microbiome profile to mice continuously maintained on LD

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