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RA is pathologically manifested as immune cell infiltration, hyperplasia of the synovial lining, pannus formation, and destruction of articular cartilage and bone ( To date, a large number of clinical trials have been performed by scientists and clinicians for testing different types of agents in RA treatment
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Full quantification may be obtained by applying a suitable pharmacokinetic model, allowing several physiological parameters to be derived, including the transfer constant (Ktrans, Box 1), fractional plasma volume (Vp), and fractional volume of the tissue extracellular space (Ve) ( 3.2.1.2
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