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GLP-1 is encoded by preproglucagon (gene name, Gcg ) and is expressed in neurons in the nucleus tractus solitarus, enteroendocrine L cells, and pancreatic alpha-cells ( Indeed, several early studies using GLP-1 immunoreactivity ( (137) ] and, therefore, called into question the physiological relevance of pancreatic GLP-1

[21] [22] Conversely, symptoms of adrenal insufficiency such as severe fatigue, weight loss, hypotension, or hypoglycemia require urgent assessment, typically starting with morning serum cortisol and possibly ACTH stimulation testing

If you are deficient in these areas, your body may struggle to convert T4 into the active T3 hormone, leaving you feeling tired even if your TSH looks "perfect" on paper