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The SHAPE study, analyzing real-world prescribing data, found: At 3 months: tirzepatide users lost 5.9% of body weight versus 3.6% for semaglutide At 6 months: 10.1% versus 5.8% At 12 months: 15.3% versus 8.3% These are averages from actual patients, not trial participants
This leads to substantial weight loss
Its effect likely arises from the modulation of the extracellular matrix and the reduction of oxidative and inflammatory stress at the tissue level [2]
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