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It has been reported that metformin and exercise can reduce osteoclastogenesis ( Our previous studies demonstrated that aerobic exercise of skeletal muscle activates AMPK and its downstream proliferation-activated receptor coactivator PGC-1, thereby increasing MOTS-c expression
Along with wide exposure of copper on the skin or mucosa, incidences of contact dermatitis have been reported although not frequently
doi: 10.1073/pnas.1611431114 89
However, indirect interactions warrant consideration
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