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studied the effect of TMAO on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model mice (Quan et al., 2023), determining 5-HT levels and its metabolites in the striatum via high-performance liquid chromatography to explore TMAOs effect on striatal neurotransmitters
These discrepancies might be attributed to the timing of GLP-1RA intervention in the disease course
Most patients begin noticing shifts in symptoms reduced flare frequency, less urgency, improved tolerance within 48 weeks, with continued improvement over 36 months
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