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A pluridimensional view of biased agonism
Cell Metab 29:10031011.e4 Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Snchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T (2017) Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Compared to classical gastroprotective peptides such as sucralfate or proton pump inhibitors (PPIs), it acts via a completely different pathway: restoration of mucosal microcirculation rather than acid reduction or formation of a mechanical protective layer
3 Moreover, L-Carnitine has been found to improve lipid profiles by reducing total cholesterol, LDL cholesterol, and triglycerides, while increasing HDL cholesterol
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