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Around 75% of people with GORD have no gastrointestinal symptoms and, as a result, do not receive treatment, but may present with other symptoms such as chronic cough
In vitro characterization is classically done on cloned human receptors expressed in cell lines (HEK293, CHO) via cAMP measurements (ELISA, FRET) or beta-arrestin recruitment (BRET, NanoBiT)
Similarly, the SUSTAIN-6 trial revealed that subcutaneous semaglutide reduced MACE by 26% in patients with type 2 diabetes at high risk for heart problems
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