Together, this cross-species comparison reveals conserved remodeling in MS and toxin demyelination models, including upregulation of core DAM signature genes and suppression of homeostatic microglial identity, though LPC notably reflects a shift toward lysosomal myelin debris clearance, whereas CPZ reflects chronic stress and metabolic adaptation
Glutathione is primarily known for its powerful antioxidant properties, which help protect cells from oxidative stress and damage caused by free radicals
Potent therapeutic GLS inhibitors, such as bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) and its analogs such as CB-839, are being actively investigated in GLS-targeting studies [38, 54,55,56,57,58]
GLOBAL GLUTATHIONE MARKET SIZE, BY TABLETS, BY REGION, 2018-2032 (USD MILLION) TABLE 65