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10 Proof-of-concept treatments were validated in Pfa1 cells, which were knocked out of endogenous GPX4 and transfected to overexpress murine mScarlet-tagged GPX4 WT (red) or GPX4 R152H (blue)

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It attaches to the skins melanocortin receptors, stimulating the creation of eumelanin the dark pigment responsible for the skins protective bronze colour

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