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Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models
PubChem CID 9941957 Lyophilisation & Stability Supplied as a sterile-filtered, lyophilised white powder under inert gas in a sealed vial
A recent study on SCI rats showed that BMSCs probably exert their biological effect through HGF-MET axis activation
10.1038/mi.2014.35 8 ChenJ.XuF.RuanX.SunJ.ZhangY.ZhangH.et al (2023a)
