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The dose escalation schedule (starting at 2.5 mg and increasing every 4 weeks) means the full effect develops over 4 to 5 months

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Women of childbearing potential should use effective contraception while taking the medication

Research Support and Efficacy Numerous clinical trials have demonstrated the effectiveness of semaglutide for weight loss: Clinical Trials : In a pivotal study involving approximately 2,000 adults with obesity or overweight (without diabetes), those using semaglutide in conjunction with lifestyle modifications lost an average of 14.9% of their body weight over 68 weeks, compared to a mere 2.4% weight loss in the placebo group