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KLF4 and Runt-related transcription factor 2 (RUNX2) synergistically enhance VSMC calcification [48]
However, no dedicated clinical trial has studied it either, and both compounds lower blood glucose through multiple mechanisms, creating additive hypoglycemia risk in certain populations
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Published literature repeatedly references interactions involving nitric oxide pathways, angiogenic signaling, fibroblast activity, collagen organization, endothelial repair, oxidative stress modulation, and neurotransmitter systems
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