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In colorectal cancer cell lines (HT-29 and SW620), knockdown of IGF-1R by small interfering RNA resulted in a blockade of the downstream PI3K/Akt and typical Wnt signaling pathways, which ultimately inhibited cancer cell proliferation and promoted apoptosis (103)
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The compound significantly enhances the effectiveness of gemcitabine in intrahepatic cholangiocarcinoma by inhibiting HDAC activity and restoring expression of pro-apoptotic genes (81)
NOGUCHI: For people who struggle with disordered eating, GLP-1 drugs can be a complicating factor
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