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GLP-1R can also suppress cardiac hypertrophy induced by Ang II through attenuating the Nox4-histone deacetylase 4 (HDAC4) axis [162]

The EDE-Q is a 28-item questionnaire adapted from the clinician-based interview Eating Disorder Examination, designed to assess the range and severity of disordered eating using four subscales (Restraint, Eating Concern, Shape Concern and Weight Concern) and a global score [26]

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Emerging competitive pressure is also building from smaller biotechnology firms developing next-generation dual and triple agonist molecules, positioning the market for intensified competition as new mechanisms of action and delivery formats advance through late-stage clinical development in the coming years