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But theres a catch: Because these medications reduce appetite so effectively, people often: Eat much less overall Miss out on protein and fiber Lose muscle mass along with fat A recent JAMA Internal Medicine patient guide emphasizes that people on GLP-1 medications commonly lose both fat and lean mass, and may experience GI symptoms that make eating harder

Patient-reported outcomes are superior in patients with type 2 diabetes treated with liraglutide as compared with exenatide, when added to metformin, sulphonylurea or both: results from a randomized, open-label study

Real GLP-1 medications produce dramatic, clinically significant weight loss

And how about side effects when switching between the two