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Complementing this, a 2024 review on NLRP3 therapeutics in DR highlighted new inhibitors like tonabersat, which block P2X7R-mediated ATP signaling in retinal microglia, decreasing IL-1/IL-18 release and microglial polarization to hinder progression from early NPDR to proliferative stages (44)
Taken together, these results are a testament both to the potential toxicity of cysteine and to the amazing ability of biological systems to safely manage their cysteine
In conclusion, the current study demonstrated, for the first time, that GSH depletion induces ferroptosis in RPE cells
Lifestyle factors including poor diet, chronic stress, excessive alcohol consumption, and environmental toxins can accelerate this decline
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