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2004 Apr;137(4):389-91

Semaglutide carries the most extensive clinical trial history of the three, including the previously cited 68-week trial reporting average weight reductions exceeding 14%, which makes it a common reference point for metabolic and receptor-signaling studies

Participants on the 5mg dose lost an average of 16.0% of their body weight

A meta-analysis of 33 randomized controlled trials (RCTs) further confirmed the renoprotective effects of statins, showing reductions in urinary albumin excretion [weighted mean difference (WMD): 2.04 mg/24 h], proteinuria (WMD: 0.58 g/24 h), and modest improvements in creatinine clearance (WMD: +0.86 ml/min) (149)