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We first showed that in the gastrocnemius muscle of the hSOD1 G93A mice, gene expression of enzymes involved in the glycolysis, TCA cycle and anaplerotic pathways such as glyceraldehyde-3-phosphate dehydrogenase, pyruvate, 2-oxoglutarate and succinate dehydrogenases, at earlier (10 weeks) and at later symptomatic stages (25 weeks) of the disease was reduced

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Kastenberg D, Bertiger G, Brogadir S

Although our sample size precluded multivariate adjustment, we acknowledge these differences as a study limitation