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After two or more weeks without administration, restarting at the full maintenance dose risks severe gastrointestinal distress because receptor adaptation has partially reversed

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"Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair." Nature

As a result of being peptides, GLP-1 RAs typically have to be given by subcutaneous (s.c.) administration as twice daily (BID) (exenatide) [15, 16], once daily (OD) (lixisenatide [17, 18] and liraglutide [19, 20]) or once weekly (OW) (dulaglutide [21, 22], prolonged-release exenatide [23, 24] and semaglutide [25, 26]) dosing regimens, based on their in vivo half-lives [6]