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Switching from tirzepatide to semaglutide or vice versa involves a transition period where receptor signaling adjusts to the new medication profile
The TRAILBLAZER-ALZ 2 (NCT04437511) trial was initially started in June 2020 as a phase 2 safety and efficacy trial, and 500 patients with early AD were recruited
Baseline micronutrient testing before starting, plus ongoing monitoring of nutrient status, is described as part of a sensible safety plan alongside hydration and electrolyte checks
Romano, M., Vacante, M., Cristaldi, E., Colonna, V., Gargante, M
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