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Check Concentration: Efficacy correlates with concentration
Mechanistically, -Syn oligomers interact with mitochondrial respiratory chain complex I, impairing its function, leading to mitochondrial membrane potential depolarization, and promoting the release of proapoptotic factors into the cytoplasm
As a result, interpretations regarding skeletal muscle preservation or loss must be made with caution, particularly in the absence of direct assessments of muscle strength or function
Drug Discov Today 13 , 268274, doi:10.1016/j.drudis.2007.12.008 (2008)
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