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Glick D, Barth S, Macleod KF
6.1.4 Activation of hexosamine pathway Hyperglycemia activates the hexosamine pathway via glutamine: fructose-6-phosphate amidotransferase (GFAT), producing UDP-N-acetylglucosamine (UDP-GlcNAc) that drives pathological O-glycosylation (66)
Compared to FoB, MZB were previously shown to use GSH through Gpx4 for protection from excessive lipid peroxidation 33 , suggesting a differential dependency on redox functions downstream of GSH synthesis
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